VueScan works with the Epson AcuLaser CX21N on Windows, Mac OS X and Linux.
You need to install an Epson scanner driver to use this scanner on Windows.
If you're using the network connection to this scanner, then you don't need to install any Epson scanner drivers. However, you might need to make sure your firewall is configured to allow VueScan to talk to your scanner.
You can use this scanner on Mac OS X and Linux without installing any other software.
If you have an iPad, iPhone, Android phone/tablet or Kindle Fire, you can use VueScan Mobile with WiFi scanners or the built-in camera to scan documents.